Prof Dr. Hans H. Hirsch emailicon
with












Tobias Bethge, PhD emailicon
Veronika Del Zenero (research technician) emailicon
page8_4Andrea Glaser (research technician) emailicon
Piotr Kardas, PhD student emailicon
Denise Kranz, Master Student emailicon
Céline Leboeuf, PhD emailicon
Julia Manzetti, PhD student emailicon
Gunhild Unterstab, PhD (research technician) emailicon
Jacqueline Samaridis (research technician) emailicon
Marion Wernli (research technician) emailicon

Former research group memebers:

Nicola Frei, Master MD

Adrian Egli, MD PhD

Rainer Gosert, PhD

Helen Hachemi, M Sc

Nina Khanna, MD

Sabrina Köhli, M Sc

David Leuenberger, Master MD




Clinical and Transplantation Virology is dedicated to clinical, virological and immunological investigations of virus infections in humans, with special emphasis on the high risk group of transplant patients and HIV-infected individuals.

Clinical studies aim at evaluating risk factors, virological and immunological diagnostic tools, and optimizing antiviral interventions.

Virological investigations focus on genetic and functional studies regarding viral fitness, immune evasion and antiviral drug resistance.

Immunological studies focus on specific humoral and cellular immunity and generating tools for diagnostics, adoptive transfer and vaccine development.

The focus of research is on polyomavirus BK and JC, herpes viruses, but respiratory viruses in the setting of immunodeficiciency.

The clinical impact of our research is strengthened by developing new virological and immunological tests which are introduced to the routine in the Molecular Diagnostics laboratory according to accredited standard procedures (Norm IEC17025).

Collaborators:

University Hospital Basel:

Transplantation Immunology and Nephrology (Prof. J. Steiger)
Hematology/Hematopoietic Stem Cell Transplantation (Profs. Jakob Passweg, Martin Stern)
Pathology Institute (PD Dr H Hopfer; Prof. D. M. Mihatsch)
Neurology (Prof. L. Kappos)


Swiss HIV Cohort Study

University of Maryland Transplant Center, USA

Pathology (Prof. Cinthia Drachenberg)
Nephrology (Prof. Emilio Ramos)

Istituto Gaslini, Genova, Italy

Nephrology (Prof. F. Ginevri)

Policlinico San Matteo, Pavia, Italy

Hematology (Prof. P. Comoli)

University Hospital North Norway, Tromsø, Norway

Medical Microbiology (Dr. Christine Rinaldo)

Helsinki University Hospital, Helsinki, Finland

Department of Virology (Prof. Irmeli Lautenschlager)

USI Università della Svizzera italiana, Bellinzona

Institute for Research in Biomedicine (Dr Davide Corti, & Prof Antonio Lanzavecchia)

Key papers: (check also on PubMed)

Hirsch HH, Vincenti F, Friman S, Tuncer M, Citterio F, Wiecek A, Scheuermann EH, Klinger M, Russ G, Pescovitz MD, Prestele H.
Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study.
Am J Transplant. 2013 Jan;13(1):136-45.

Hirsch HH, Randhawa P; T Infectious Diseases Community of Practice.
BK Polyomavirus in Solid Organ Transplantation.
Am J Transplant. 2013 Mar;13 Suppl 4:179-88.

Hirsch HH, Lautenschlager I, Pinsky BA, Cardeñoso L, Aslam S, Cobb B, Vilchez RA, Valsamakis A.
An international multicenter performance analysis of cytomegalovirus load tests.
Clin Infect Dis. 2013 Feb;56(3):367-73.

Hirsch HH, Martino R, Ward KN, Boeckh M, Einsele H, Ljungman P.
Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus.
Clin Infect Dis. 2013 Jan;56(2):258-66.

Koskenvuo M, Dumoulin A, Lautenschlager I, Auvinen E, Mannonen L, Anttila VJ, Jahnukainen K, Saarinen-Pihkala UM, Hirsch HH.
BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission.
J Clin Virol. 2013 Jan;56(1):77-81.


Gosert R, Kardas P, Major EO, Hirsch HH.
Rearranged JC virus noncoding control regions found in progressive multifocal leukoencephalopathy patient samples increase virus early gene expression and replication rate.
J Virol. 2010 Oct;84(20):10448-56. doi: 10.1128/JVI.00614-10. Epub 2010 Aug 4.

Unterstab G, Gosert R, Leuenberger D, Lorentz P, Rinaldo CH, Hirsch HH.
The polyomavirus BK agnoprotein co-localizes with lipid droplets.
Virology. 2010 Apr 10;399(2):322-31

Rinaldo CH, Gosert R, Bernhoff E, Finstad S, Hirsch HH.
1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells.
Antimicrob Agents Chemother. 2010 Nov;54(11):4714-22.

Egli A, Infanti, L., Dumoulin, A., Buser, A., Samarides, J., Stebler, C., Gosert, R., Hirsch, H.H.
Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors.
J Infect Dis 2009 March 15; 199(6): 837-46

Khanna N, Wolbers, M., Mueller, N.J., Garzoni, C., DuPasquier, R.A., Fux, C.A., Vernazza, P., Bernasconi, E., Viscidi, R., Battegay, M., Hirsch, H.H.
JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.
J Virol 2009 May; 83(9): 4404-11

Gosert, R., Rinaldo, C. H., Funk, G. A., Egli, A., Ramos, E., Drachenberg, C. B., and Hirsch, H. H.
Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology.
J Exp Med 205: 841-5 (2008).

Bernhoff E, Gutteberg TJ, Sandvik K, Hirsch HH, Rinaldo CH (2008)
Cidofovir Inhibits Polyomavirus BK Replication in Human Renal Tubular Cells Downstream of Viral Early Gene Expression.
Am J Transplant 8: 1413-1422

Funk GA, Gosert, R., Comoli, P., Ginevri, F., Hirsch, H.H.
Polyomavirus BK replication dynamics in vivo and in silico to predict cytopathology and viral clearance in kidney transplants.
Am J Transplant 2008;8:2368-2377

Khanna, N., Widmer, A. F., Decker, M., Steffen I., Halter, J., Heim, D., Weisser, M., Gratwohl, A., Flueckiger, U., Hirsch, H. H.
Respiratory Syncytial Virus Infection in Hematological Patients: Single Center Study and Review of the Literature
Clin Inf Dis 46: 402-412 (2008).

Ginevri F, Azzi A, Hirsch HH, Basso S, Fontana I, et al. (2007)
Prospective monitoring of polyomavirus BK replication and impact of pre-emptive intervention in pediatric kidney recipients.
Am J Transplant 7: 2727-2735.

Binggeli S, Egli A, Schaub S, Binet I, Mayr M, Steiger, J., Hirsch, H.H. (2007)
Polyomavirus BK-Specific Cellular Immune Response to VP1 and Large T Antigen in Kidney Transplant Recipients.
Am J Transplant 7: 1131-1139.

Funk, G. A., Gosert, R., Hirsch, H. H.
Viral Dynamics in Transplant Patients: Implications for Disease.
Lancet Inf Dis 7: 460-472 (2007).

Hirsch, H. H., Brennan, D. C., Drachenberg, C. B., Ginevri, F., Gordon, J., Limaye, A. P., Mihatsch, M. J., Nickeleit, V., Ramos, E., Randhawa, P., et al. (2005)
Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations.
Transplantation 79, 1277-1286.

Hirsch, H. H., and Steiger, J. (2003).
Polyomavirus BK.
Lancet Infect Dis 3, 611-623.

Hirsch, H. H., Knowles, W., Dickenmann, M., Passweg, J., Klimkait, T., Mihatsch, M. J., and Steiger, J. (2002).
Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients.
N Engl J Med 347, 488-496.

Nickeleit, V., Klimkait, T., Binet, I. F., Dalquen, P., Del Zenero, V., Thiel, G., Mihatsch, M. J., and Hirsch, H. H. (2000).
Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy.
N Engl J Med 342, 1309-1315.